How do you handle input and output in files using Python?

The appropriate method for handling input and output in files using Python involves the use of the open(), read(), write(), and close() functions.

Opening a file with the open() function is the crucial first step, allowing programmers to specify the file they want to work with and the mode (such as read, write, or append) in which to open it. Once the file is open, you can use the read() function to retrieve data from the file or the write() function to add data to it. These functions are pivotal in managing the content within the file.

After completing the operations, it is important to use the close() function to properly shut the file. This ensures that any changes are saved and frees up system resources, preventing potential issues such as data corruption or memory leaks.

The combination of these functions allows for a systematic and safe approach to file I/O operations in Python, making this answer the most accurate option presented.